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Caffarini, J, Gjini, K, Sevak, B, Waleffe, R, Kalkach-Aparicio, Poly, M and Struck, AF (2021)

Engineering Nonlinear Epileptic Biomarkers Using Deep Learning and Benford’s Law

Preprint posted on; last accessed December 15, 2021.

ISSN/ISBN: Not available at this time. DOI: 10.21203/

Abstract: In this study we designed two deep neural networks to encode 16 feature latent spaces for early seizure detection in intracranial EEG and compared them to 16 widely used engineered metrics: Epileptogenicity Index (EI), Phase Locked High Gamma (PLHG), Time and Frequency Domain Cho Gaines Distance (TDCG, FDCG), relative band powers, and log absolute band powers (from alpha, beta, theta, delta, gamma, and high gamma bands. The deep learning models were pretrained for seizure identification on the time and frequency domains of one second single channel clips of 127 seizures (from 25 different subjects) using “leave-one-out” (LOO) cross validation. Each neural network extracted unique feature spaces that were used to train a Random Forest Classifier (RFC) for seizure identification and latency tasks. The Gini Importance of each feature was calculated from the pretrained RFC, enabling the most significant features (MSFs) for each task to be identi ed. The MSFs were extracted from the UPenn and Mayo Clinic's Seizure Detection Challenge to train another RFC for the contest. They obtained an AUC score of 0.93, demonstrating a transferable method to identify interpretable biomarkers for seizure detection.

@misc{, author = {Joseph Caffarini and Klevest Gjini and Brinda Sevak and Roger Waleffe and Mariel Kalkach-Aparicio and Melanie Boly and Aaron F Struck}, title = {Engineering Nonlinear Epileptic Biomarkers Using Deep Learning and Benford’s Law}, year = {2021}, url = {}, }

Reference Type: Preprint

Subject Area(s): Biology, Computer Science